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Site and function independent models clearly do not capture critical elements of protein evolution.
This ability to distinguish between site and function of HER4 and its fragments is particularly important, with recent evidence highlighting the different functions of nuclear and mitochondrial HER4.
As shown in the 3D protein structure prediction model, loops L1, L3, and L9 are hypothetically oriented around the enzyme active site and function in the flexibility of the substrate-binding pocket.
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These agents are divided according to their mode of action into colchicine site binder, vinca-alkaloid related drugs and those interacting with the Taxol binding site and functioning as stabilising agents.
Ser216 lies on the active site and functions in the activation of Cys215[43].
In the amidohydrolase superfamily (AHS) of enzymes, this invariant aspartate residue (Asp-313 in E. coli CodA) coordinates one of the divalent cations in the active site and functions in proton transfer reactions.
Importantly, in cBAF-perturbed cancers, ncBAF complexes maintain gene expression at retained CTCF-promoter sites and function in a manner distinct from fusion oncoprotein-bound complexes.
Homeostatic chemokines are primarily expressed at lymphocyte-homing sites and function to maintain homeostasis and regulate homing and lymphocyte maturation.
However, seventeen of the 44 contain only SPI-1 binding sites and function in defense response, the pentose phosphate shunt, inositol phosphate signaling, and S100A signaling.
In the context of nuclear structure, a significant portion of LINEs seem to be ORC-binding sites and function as MARs.
However, the mechanisms by which these complexes recognize their target sites and function together to form repressive chromatin domains remain poorly understood.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com