Exact(6)
We have found that SAR decreases with time-multiplexing in SE SIR EPI due to the fewer refocusing pulses needed (reduced by the SIR factor), compared to conventional SE-EPI.
As calibration data, an acquisition with matched SIR factor, and a MB = 1 excitation was obtained.
This would yield a relatively higher SNR for the lower SIR factor acquisitions and potentially better fMRI performance.
Further, given the fact that the highest readout bandwidths were not used for the lower SIR factor acquisitions, and because of echo spacing limitations imposed by the software, significant gains in SNR would not have been achieved and would have come at the expense of other parameters.
Finally, repression at silencer-proximal genes far from telomeres was facilitated by SIR factor overexpression, as well as by compromising telomere anchorage (Maillet et al, 2001; Gartenberg et al, 2004; Taddei et al, 2009).
Silencing in yeast is highly sensitive to local Sir factor concentration, and is therefore strongly enhanced by the recruitment of silencers and silent domains to the nuclear envelope [ 75], where Sir proteins accumulate in foci that colocalize with clusters of yeast telomeres.
Similar(2)
In principle the readout train length could have been varied for the different SIR acquisitions, resulting in lower bandwidths for the less accelerated data, while matching the distortions of the data with the higher SIR factors.
Moreover, loss of DOT1 causes redistribution of the SIR factors and this could also influence the vitality of cdc13-1 cells.
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