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The observation that mutated and unmutated subsets of CLL have distinct clinical courses is consistent with a two-cell origin model; however, the homogeneous gene expression signature, with only minor differences between unmutated and mutated CLL, suggests a singular originating cell and the one-cell model.
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The study of generalized Calderón-Zygmund operators and strongly singular non-convolution operators originated in the classical Calderón-Zygmund operator.
Particulary, the great importance of singular integral theory, which originated in Fourier analysis, must be emphasized here.
In recent years, Calderón-Zygmund's theory of linear and nonlinear PDEs with VMO coefficients was immensely developed, which naturally originated from the singular integral operators and the estimates of commutators with a VMO function [8, 9].
The Health Locus of Control, Self-Regulatory model, TPB and TTM all had the weakness that they tended to originate from a singular viewpoint which results in limited integration of the sources of influence, and thus they were able to account for limited variability in the dependent variable.
It is derived from Ancient Greek lepidos or λεπίδος (scale), itself originating from the Greek lepis (female genitive singular form lepidos) meaning "(fish) scale" (and related to lepein "to peel") and pteron or πτερόν (wing).
Here I argue that the eukaryotic cell originated in a unique prokaryotic endosymbiosis, a singular event that transformed the selection pressures acting on both host and endosymbiont.
"The extremely poor quality of Wells Fargo's loans was a function of management's nearly singular focus on increasing the volume of FHA originations — and the bank's profits — rather than on the quality of the loans being originated," Bharara's office said.
So it makes continuing sense to persevere in pressing that singular insight, in pursuing a determination to confront a dysfunctional system where it originates.
First of all, we have the approach originating with Bernstein, whose approach is to translate boundary value problems to the corresponding singular integral equations, then use the properties of the Fredholm operator to discuss the solvability of singular integral equations (see [5]).
Singular "therapist," plural "their," singular "her".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com