The enhanced repopulating ability of compound Gata2 +/− ; 5A3 +/del vs Gata2 singly mutant HSC achieved borderline statistical significance in three myeloid populations (KLS (p = 0.09), MP (p = 0.09), and myeloid cells (p = 0.12)).
Similarly, conventional metabolic designs often singly focus on achieving maximal production rates or yields of targeted compounds without accounting for adverse economic consequences (e.g., due to material costs or final product purification processes) that may ultimately make a design impractical or commercially infeasible.
Though syntheses of singly substituted glycopeptides are routinely achieved, the complexity of most glycoproteins and glycopeptides presents a formidable challenge.
Similar to ECD, in ETD, the electron delivery is achieved through the singly charged anions (e.g., fluoranthene anions) to the multiply protonated peptides.
Excluded variables were then reintroduced singly into this model but none achieved significance.
The IMS resolving power achieved was ∼73 for singly-charged ions, very close to the predicted diffusion-limited resolving power (∼75).
Emerging clinical usage and pharmacological effects have been achieved in using Rehmanniae Radix either singly or in combination with other herbs to treat skeletal diseases in traditional Chinese medicine (TCM) in the recent years.
However, control of downy mildew was not achieved with the organic products tested singly in 2012 and the combination programs tested in 2013, 2014, and 2015, which were all applied with a boom with three nozzles per plant, two of which were drops.
The vast majority of multiply phosphorylated peptides were captured during the first IMAC, whilst most singly phosphorylated ones were seized during the second enrichment, achieved with titanium dioxide.
Lipid identification was achieved by collision-induced dissociation (CID) of singly charged (M−H)− or (M+H)+ parent ions using a "Nth order double play" experimental method, alternating from full-scan to CID fragmentation (eV35) of the eight most intense peaks detected during a 45 min LC-gradient.
In theory, this could be achieved if we could use the susceptibility alleles, singly or in combination, to define a subgroup of men who harboured the majority of cancers.
