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Radiolabelled somatostatin analogues have been tested as a single therapy for SCLC, but this has not been as promising as predicted, based on preclinical study results [17 19].
Combination therapy outperforms single therapy for hemostasis.
Further research may yet establish the use of parenteral oestrogen as a safe, effective and cheap single therapy for the treatment of prostate cancer, which could avoid some of the toxicities of present-day castration.
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Combination therapy, in which two or more agents are applied, is more effective than single therapies for combating cancer.
Available antifibrotic agents (ie, pirfenidone and N-acetylcysteine) have limited efficacy as single therapies for IPF; therefore, further study of combination therapy with antifibrotic agents is needed.
Although there is an increasingly large number of trials that compare various analgesics to placebo, very few directly compare single therapies for which an evidence base exists, or address the issue of combining treatments [ 27].
More than 75 inhibitors of angiogenesis have been included in clinical trials, but only few of them were found to be efficient as single-therapy for advanced tumors [27].
"People who say CBT is superficial have just missed the point," said Trudie Chalder, professor of cognitive behavioural psychotherapy at the King's College Institute of Psychiatry, Psychology and Neuroscience in London, who argues that no single therapy is best for all maladies.
In the initial experiments, nude mice with s.c. FaDu tumours (V=220±45 mm) were treated with single therapy and analysed for inhibition of tumour growth.
Given their extremely heterogeneous nature, the assumption that a single therapy could be beneficial for all patients is no longer plausible.
Therefore, no single therapy is completely effective for NPC treatment.
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