Exact(3)
For example, a single synthetase that adds Val to all tRNAs with 2nd anticodon base = A would be sufficient to assign all NUN codons to Val.
Although anti-ARS antibodies may be found together with other antibodies in some patients (for example, frequently with Ro52), it is noteworthy and intriguing that individuals with anti-ARS antibodies rarely target more than a single synthetase.
This would either require a very complex recognition process for a single synthetase, or it would require separate synthetases for each codon block that would carry out the same reaction of charging the tRNA with Asp.
Similar(57)
In many cases, a genome encodes a single lanthipeptide synthetase, but a large number of substrates.
A single microcystin synthetase (mcy) gene cluster (Fig. 1) has been shown to be responsible for all structural variants of microcystins [ 4, 5].
More than 70 variants of microcystins are known, and a single microcystin synthetase (mcy) gene cluster consisting of 10 genes (mcyA to mcyJ) has been identified to be responsible for the production of all known variants of microcystins.
In M. tuberculosis, a single pRpp synthetase enzyme (Mt-PrsA) is solely responsible for the generation of pRpp, by catalyzing the transfer of pyrophosphate from ATP to the C1 hydroxyl position of ribose-5-phosphate.
The splice sites data for L. major at the tritrypdb server suggests an alternate start site as a result of trans splicing in the promastigote stages for several tRNA synthetases including the single copy tRNA synthetases such as the valyl, isoleucyl, leucyl, glutamyl tRNA synthetases [Additional file 1: Table S1].
The single tyrosyl-tRNA synthetase (TyrRS) gene in trypanosomatid genomes codes for a protein that is twice the length of TyrRS from virtually all other organisms.
CGP is a polypeptide that results from non-ribosomal protein synthesis by a single enzyme, cyanophycin synthetase (CphA) (Ziegler et al. 1998).
Hence, it is possible that the single copy tRNA synthetases are probably transported to mitochondria during translation although PSORT II is unable to predict the possibility of mitochondrial localization for the single copy ones.
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