It is believed that part of the missing heritability is explained by gene-gene interactions, that might be even more important than the independent effects of the single susceptibility genes.
The report from Newton-Cheh et al. [ 24] highlights the effort required to robustly explore just a single susceptibility locus for hypertension.
A single susceptibility locus to PDS has been mapped on chromosome 7q35-q36 but the candidate gene is yet to be identified [ 3].
However, most previous studies have evaluated the effects of only a single susceptibility gene, and hence prediction based on such information is not as reliable.
Examination of a single susceptibility gene can separate the study population into only two risk groups, those with and those without the mutation.
An alternative set of mouse models, beyond the naturally occurring lupus strains discussed above, consists of knockout or transgenic genetic modifications that profoundly affect a single susceptibility gene.
Furthermore, the impact of xenobiotic-metabolizing enzymes and transporters could determine the functional results in the risk of HNC over the independent effects of each single susceptibility gene.
However, most previous OA genetic studies have evaluated the effects of only single susceptibility genes, which are mostly small, and hence predictions based on their results are not always useful.
However, in murine lupus study of allelic polymorphisms has been greatly aided by the ability to create congenic mice in which a single susceptibility allele, or small cluster of alleles, are back-crossed onto a normal genetic background.
Transforming the data into a single susceptibility value by averaging the 100 and 50 PFU response groups for each strain indicated that B6-ChrY consomic strains exhibit a continuous distribution of CVB3-induced mortality phenotypes.
This poses challenges to an industry that is increasingly offering personal genome tests that consist of more and more susceptibility tests for more and more diseases rather than single susceptibility tests for single diseases.
