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Shifting Foci of Hematopoiesis during Reconstitution by Single Stem Cells.
Shifting foci of hematopoiesis during reconstitution from single stem cells.
Kanatsu-Shinohara, M., Toyokuni, S. & Shinohara, T. Genetic selection of mouse male germline stem cells in vitro: offspring from single stem cells.
In the early 1970s, following the finding that the epidermis had an ordered structure, he proposed that the skin was organised into "epidermal proliferative units" in which single stem cells lay at the bottom of larger, organised columns of daughter cells, which matured into flattened dead cells as they moved towards the surface and were shed.
The researchers discovered the symmetric fate decisions using a technique that genetically marked single stem cells in mouse hair follicles; Tumbar and her colleagues could track all the progeny of the marked cells because the technique prompted them to turn blue under experimental conditions.
The analysis supports experimental evidence for the dominance of single stem cells and their progeny in tissue maintenance and carcinogenesis.
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Similarly, when the stem cell is ablated in the prothallus, a single stem cell is regenerated9.
Gobaa, S. et al. Artificial niche microarrays for probing single stem cell fate in high throughput.
Shackleton M, Vaillant F, Simpson KJ, Stingl J, Smyth GK, Asselin-Labat ML, et al. Generation of a functional mammary gland from a single stem cell.
This is the same research team that produced a single stem cell line from a cloned embryo.
A single stem cell at the bottom of a pocket divides, and its daughter cells are pushed up the pocket walls.
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