Your English writing platform
Discover LudwigExact(6)
Our analysis shows that the most complex methods are not significantly better than the simplest one, a univariate model relying on a single proliferation gene.
Interestingly, AURKA, the simplest model defining the risk score as the expression of a single proliferation gene, performed well in all the survival prediction tasks.
Carcinogenesis is simplified because mutations in oncogenes and tumour suppressor genes, which constitute multiple independent steps, are lumped into a single proliferation term.
The first risk prediction method is also the simplest one and defines the risk score as the expression of a single proliferation gene (AURKA) well studied in literature (Hanahan and Weinberg, 2000).
Genotype: it can be the expression of a single proliferation gene (AURKA), the expression of a biologically driven selection of genes of interest (BD) or the expression of the whole genome (GW).
In total, these analyses show that a combination of ER, HER2, and a single proliferation biomarker (i.e., AURKA) is prognostic, but is suboptimal to capture the biological diversity of breast cancers, which has similar implications for the capture of this biological diversity using IHC-based methods.
Similar(54)
However in this case, it appears that perisurgical ketorolac may dramatically reduce the initiation of surgery-induced angiogenesis as well as single cell proliferation after surgery.
The clonogenic cell survival assay is an effective method for the determination of single cell proliferation capacity, thereby retaining its reproductive ability to form a large colony or a clone [ 30, 31].
Mr Bush has singled out proliferation of weapons of mass destruction as the greatest threat America faces.
Confirming this further, an overall FEM score computed over all significant FEM module genes correlated reasonably well with a single-gene proliferation index (PCNA expression) (Pearson correlation ∼0.38, P < 10−10).
Aboard Air Force One, a senior Bush administration official told reporters that Russian aid to Iran involved "the single most important proliferation threat there is".
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com