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Nanoparticle biodistribution, at single particle resolution, is studied by transmission electron microscopy.
We have been able to observe with single particle resolution the interface between two structural symmetries that cannot be interconnected by a continuous transition.
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A suspended microchannel resonator (Archimedes, Affinity Biosensors LLC) was used for size characterization of the fractionated phosphors at single-particle resolution with low-femtogram sensitivity.
Resistive-pulse sensing with nanopores detects MDa-sized biomolecules with single-particle resolution and can be used to understand population heterogeneity.
SPARX (single particle analysis for resolution extension) is a new image processing environment with a particular emphasis on transmission electron microscopy (TEM) structure determination.
To perform similar experiments with non-crystalline material, that is single particles, the resolution-dependent fading of the signal present in an image (or average of images) has to be determined.
Therefore, the method may facilitate the analysis of experimental data in high resolution single particle electron cryomicroscopy.
For our primary goal, "irradiation of cell organelle with a single particle with a position resolution of 2 μm in a reasonable irradiation time", special features are considered.
For our primary goal, "irradiation of a cell organelle with a single particle with a position resolution of 2 μm in a reasonable irradiation time," special features are considered.
Using a 2.6 Å resolution single particle cryo-EM reconstruction of rotavirus VP6, determined from movies recorded with a total exposure of 100 electrons/Å, we obtained accurate measurements of optimal exposure values over a wide range of resolutions.
capsulatus consist of 1189 residues and 129 kDa, so this large three-lobed structure, determined by single particle reconstruction at a resolution of 25 Å [ 17], is required for its core catalytic functions.
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