The single mutation that creates Tamiflu resistance appears to be spontaneous, and not a reaction to overuse of the drug.
Only a single mutation in the virus gene is needed to create resistance to the non-nucleosides.
While studying the genetics of hemoglobin, the molecule that carries oxygen in blood, he found that this single mutation caused production of abnormal variants of the protein.
Each had a mutation in the gene, but, remarkably, nearly everyone had a different one; there was no single mutation that caused Lesch-Nyhan.
But he thinks it can only go backward when the evolution of the trait is simple, like when a single mutation is involved.
The defects may be the result of several minor genetic mutations rather than the single mutation that produces seizures in the rare, highly heritable forms of epilepsy.
No single mutation could allow the viruses to start latching onto OmpF.
Haldane favored the single mutation mechanism, but Fisher and Wright backed multiple gene change.
Confirmation of single mutation by PCR in this study.
(B) A single mutation (T178G) present in the K113 fadR revealed by direct DNA sequencing.
This single mutation did not affect the soluble expression level of Rubisco (Fig. 3F).
