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It took two years for Congress to make just a single modification in the pension rules, changing an interest rate that companies use when calculating pension values.
Once bound, the new method made a single modification, changing the letter A to I (which a cell interprets as G).
It's a provocative argument, and one that Ericsson still espouses over two decades later, having made a single modification to his list of exceptions: body size joined height as one of only two areas with any possible genetic influence.
Both single modification and co-modification extended the light absorption of TiO2 NTAs to the visible light range.
SAR analysis of derivatives modified at the C-3 and C-3″ positions suggested that single modification at C-3 or C-3″ was effective for in vitro antibacterial activity.
While a single modification with either the specific or CPP ligand showed no increase in targetability, the dual-ligand enhanced the amount of delivered liposomes after systemic administration to OS-RC-2 xenograft mice.
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Furthermore, the complexity of post-translational modifications of p53 needs to be taken into consideration to reveal the functional significance of the single modifications as well as the sequential interplay of different modifications [38].
We next explored single modifications at cysteines, which are paired in two disulfides in CRM197.
Analysis of the double and single modifications by western blotting gave results that broadly supported the conclusions from the immunostaining.
This property led to the suggestion that epigenetic regulation recognises patterns of post-translational modifications (words) rather than single modifications (letters) (Ref. 130).
For siRNAs containing these dinucleotide sites, even single modifications to the sugar backbone within the sites were sufficient to significantly increase stability.
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