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The rate constants satisfy the Arrhenius equation, suggesting a single mechanistic pathway for the annihilation process in the temperature range; wherein the activation energy decreases with increasing dose for all radicals, possibly due to higher concentrations of free radicals in close proximity produced at higher doses.
In fact to date, although we know that age, gender, genetics, and environment all play a role in the disease, there has been no single mechanistic hypothesis, aside from that discussed herein, that explains all of the known features and risk factors for the disease.
As highlighted in a recent review on sex and SLE, it is incorrect to combine all autoimmune diseases into a single mechanistic construct [ 80].
So far, no theoretical account has been able to reconcile and explain these findings by means of a single, mechanistic neural model.
It is important to note that differences in animal models in terms of dietary composition, timing, and length of exposure confound the development of a single mechanistic model of programming.
This fits well to the detected hormetic effect of midazolam, as hormesis is generally understood not to be based on a single mechanistic pathway, but rather reflects a complex pattern of cellular reactions to an unspecific sublethal stimulus.
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Developmental toxicity can be caused through a multitude of mechanisms and can therefore not be captured through a single simple mechanistic paradigm.
The bending of all the expression length curves at the transition from moderate to high expression levels (fig. 1) seems to be incompatible with a single underlying mechanistic cause.
Setting our sights on the future, we will close by highlighting the importance of reconciling both NPC structure and function, as we strive towards converging on a single conceptual, mechanistic understanding of the NPC.
Although we remain tantalized by the prospect of a series of high-resolution liganded stuctures in states comprising the entire catalytic cycle, with accompanying biophysical data, we should remain sanguine and appreciate that a single unifying mechanistic model of transport may not apply to this diverse family of intriguing proteins.
The knowledge derived from these two approaches can also inform each other, with single-chemical mechanistic and genetic data potentially useful in mixtures research, and an improved understanding of how combinations of multiple endogenous and foreign chemicals behave in the body contributing to better characterization of the toxic effects from single chemicals.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com