Exact(27)
Haplotype analyses further supported the results of single marker analyses.
The combined data analysis agrees with single marker analyses on the close relatedness of C. obovatifolium, C. oligophlebium and C. ramosii with Pyrostria (PP = 0.99; BS = 85%).
The FBAT single marker analyses were performed under an additive genetic model for each SNP and the three studied phenotypes.
We downloaded the Hindorff dataset on the 21st May 2010, at which point it contained 2727 unique SNPs with results for single marker analyses.
Additionally, it has been shown that haplotype analyses can detect associations if there are multiple risk alleles at a single locus when single marker analyses may not [19].
After single marker analyses were completed, haplotype analyses with multiple markers were performed to determine risk haplotype and estimate the size of the associated region.
Similar(33)
Within-family results from the least squares single-marker analyses were used in expectation-maximization likelihood IM and CIM implemented with QTL Cartographer.
Power and map resolution of the proposed method were assessed by simulation, and we show that for the same data set, multiple-marker mapping performed better than the commonly used single-marker analyses.
Haplotypes often provide greater statistical power than single-marker analyses, for genotype-phenotype association studies.
Haplotype analyses are known to be more powerful than single-marker analyses for the detection of a genomic region that is enriched for phenotype-relevant mutation(s)/causal variant(s).
Strict replication criteria were used in the single-marker analyses (Konig 2011).
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