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That array platform was designed to increase genome coverage by targeting multiple gene models from single loci based on TIGR/RGAP annotation.
Metagenomes targeted to single loci such as 16S rRNA studies were excluded as well.
Multilocus haplotypes may capture the LD information in a gene better than methods based on single loci [3].
All 49 sequences were mapped to single loci in the human genome using the NCBI BLAST tool (Table 2).
In S. pombe, the Sipiczki laboratory isolated a number of caffeine-resistant mutants which defined single loci.
Our data show that some degree of variability exists at F8 single loci and at LINE-1 and Alu repeats.
Our results corroborated the theoretical expectation that increasing the number of loci impacted the accuracy of the estimate more than increasing the sequence length at single loci.
Maximum likelihood and Bayesian analyses were performed with both datasets and with single loci as well as multi-gene alignments including all sequence fragments.
Among other reasons, failure to identify and replicate individual genetic risk factors for complex diseases has been attributed to epistasis obscuring the effect of single loci [33], [34].
Repressive histone marks are most likely not involved, since loss of histone methylatransferases or DNA methylatransferases do not effect peripheral localization of single loci [15], [17].
EST-cluster to genome alignments were used to map the 1,670 clusters to single loci at greater than 97% query coverage.
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