Single, inhaled doses of UTP stimulate mucociliary clearance in conscious, intubated sheep and in patients with mild chronic bronchitis (smokers and former smokers), suggesting that UTP may be useful for obtaining deep-lung sputum specimens suitable for diagnostic purposes.
Objective: This meta-analysis aimed to determine the efficacy of fluticasone propionate and salmeterol inhaled from a single inhaler (combination therapy) or from separate inhalers (concurrent therapy).
The convenience of a single inhaler was reflected in comments such as 'When I felt wheezy it [the inhaled steroid] didn't stop it, the blue one does.
In this work, Technegas was inhaled with a single full inhalation, but subsequent imaging was performed with the subject breathing normally in supine position.
In the supportive TQT study, subjects (n = 40) were randomized to single-dose inhaled FF(4000 μg), oral moxifloxacin (400 mg) or placebo.
Volunteers inhaled single breaths of citric acid from a modified 646 De Vilbiss nebuliser controlled by the KoKo DigiDoser (Pulmonary Data Service Instrumentation Inc., Louisville, CO, USA).
Subjects inhaled single breaths (from Functional Residual Capacity (FRC) to total lung capacity (TLC)) of capsaicin aerosol from a compressed air-driven nebulizer (model 646, Technipro, North Parramatta, Australia) controlled by a dosimeter (KoKo Digidoser 323200; Technipro Marketing Pty Ltd., Sydney, New South Wales, Australia).
Following both single and repeat inhaled administration of FF 800 μg there were consistently higher Cmax and AUC values in all three East Asian groups with geometric mean ratios for Cmax and AUC ranging from 40%to76%6% greater and 52%to75%5% greater, respectively, compared with the Caucasian group (Table 3).
Studies have suggested that patients on LABA and LAMA bronchodilator therapy (once daily LAMA plus twice daily LABA) have poor persistence rates, yet instead of dealing with the adherence issues they are often switched to a combination product combining a single bronchodilator and inhaled steroid [ 7].
