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Consequently, a single indication of pathogenicity in STEP3, although measuring different aspects of the protein function than the MMR assay, was deemed sufficient to confirm variant pathogenicity.
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The algorithm assigned each test a single indication irrespective of the number of reasons (or missing data) recorded by chart auditors (see Figure 2).
This trend was evident for both medical services diagnostic codes as well as prescriptions by other physicians of single indication drugs.
Requiring multiple dementia indicators enhances the validity of case group assignment but also selects more severe cases, whereas relying on one single indication implies a higher risk of false-positive classification.
CRITICAL ISSUES: Insufficient preclinical data have accumulated to enable clinical development of metalloporphyrins for any single indication.
Many of the currently available biosimilars were approved in every indication of the originator after testing in a single indication.
The included randomized trials addressed diverse clinical indications for hyperoncotic albumin, and the number of trials focusing on any single indication was, in most instances, relatively small.
Overall, 73% of the problems assessed were considered valid; 42% originated from medical service diagnostic codes, 11% from single indication drugs, and 47% from prescription indications.
Both the ACT and ACQ are validated tools that are reliable and responsive to changes in asthma control over time, and provide a single numerical indication of control that has the potential to provide a target to drive management, analogous to that of a blood pressure measurement or a lipid measurement for management of hypertension or dyslipidaemia.
The Mets can only hope that his sixth-inning single was an indication of a better season ahead.
The measure "gives you, in a single number, an indication of which side is benefiting from all of the cracking and packing and how large of an advantage they have," Stephanopoulos said.
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