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At most nucleotide positions, the SHAPE-reactivity change patterns follow single exponential decay.
Based on our model, it can be hypothesized that in these patients the number of CML cells declines in a single exponential phase during treatment (Figure 3a), or according to the reverse biphasic decline pattern (Figure 3b).
The quadratic term is determinant for the TCP for the low-LET radiation, leading to higher TCPs for the single-exponential clearance pattern and to TCPs of 0 when the quadratic LQ model term β is neglected.
These two different dynamical patterns (characterized as "single exponential" or "non-exponential") stratified the population.
The two-state nature of the process is indeed apparent in several complementary observations that do not depend on the measured timescales: (1) the single exponential distribution of lifetimes; (2) the distribution of molecular extensions; (3) the binary switching patterns observed in the experimental traces; (4) and the results from the HMM model.
The lines for the 16 items appeared to cross at a single point between 'Rarely' and 'Some', whereas the distributions of the 16 items between 'Some' and 'Most' followed an exponential pattern with the same parameter.
A single exponential was fitted to the resulting decay curve.
Run length was fit to a single exponential ± confidence interval.
Kinetic folding of this domain showed multiple exponential phases, whereas unfolding showed a single exponential phase.
All steps are well described by single exponential kinetics.
The relaxation data were fit using either a double or single exponential decay function.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com