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Single exchanges of basic aa either N- or C-terminal of the TMD did not alter the strict mitochondrial localization (Fig. 3B, i l; q t, 3C), nor did the exchange of two basic aa N-terminal of the TMD (GDAP1[K314A R315A], Fig. 3C) or flanking HD1 (GDAP1[K291A R310Q], Fig. 3C).
2. Single exchanges to the GTGGGAA consensus might exist.
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