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Conclusion: These observations suggest that technologies which are simple to apply, and have a single endpoint, show concordance between RCT results and clinical use (HUAM, short-term tocolysis, single-course BMZ, TRH, and fFN).
Formulae corresponding to the commonly used methods in a single endpoint study, which were proposed by [Blackwelder, W.C., 1982. Proving the null hypothesis in clinical trials. Controlled Clinical Trials 3, 345 353] and [Farrington, C.P., Manning, G., 1990.
This approach will make it possible to go beyond the calculation of a single endpoint for each subject, and to translate the trial findings into definitions of effectiveness and outcomes that will be relevant to the ongoing debate concerning how best to relate the benefits of such medications to their costs.
Content consumers like Plaxo and MyBloglog benefit from a single endpoint and a standardized way of accessing data.
It also features clustering capabilities that allow multiple devices to be connected and accessible through a single endpoint.
This will serve as a single endpoint to draft new versions of the dictionaries.
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However, most of the studies mainly focused on the datasets with the single endpoints.
Therefore, this method of measurement was avoided and single endpoints (T24) method of measurement was chosen.
Based on our analyses investigating the single endpoints, we were interested to know whether this increased risk of the combined primary endpoint was mainly explained by the effect of homoarginine on sudden cardiac and heart failure deaths.
In the context of medical research into the efficacy or effectiveness of an intervention the term 'outcomes' has often been interpreted to mean single endpoints with a linear cause and effect link to an external intervention.
Not all these research methods require the measurement of 'before and after' primary quantitative outcomes and the reduction of change in health, wellbeing and health-related behaviours to single endpoints is unlikely to answer the questions posed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com