In addition, expression correlation between gene pairs was generally two-fold higher in recent duplicates than in single duplication events.
For this reason, it was rightly suggested already in the 1930s that new genes originate by whole gene duplication [ 117]: First, a previously complete and active gene is duplicated by a single "duplication mutation" all at once along with its regulatory and coding sequences.
It has been proposed that neofunctionalization is a common fate for duplicates that have been created by a single duplication event and avoided pseudougenization, in contrast to members of large gene families [ 20].
For example, if protein A hits proteins B and C with BLASTP E-values ≤ 10−10 and identity ≥ 40%%, then A, B, and C were included in the same family, regardless of the similarity for the comparison of B and C. Linked duplicate sets, which comprised the duplication of multiple open reading frames via a single duplication event, were treated as a single gene duplicate.
The duplicated genes were identified using the phylogenetic method, limited to a single duplication event per lineage.
Until IfcConnectedFaceSet it remains single duplication, but when defining faces and corresponding coordinates, it becomes clear why the file size bloats up.
Thus, the majority of the CNVs detected may be biallelic, which involves either a single duplication or a single deletion.
This phenomenon corresponding to a single duplication event is found in a few individuals from different haplogroups, and has occurred more than once in the history of goats.
The phylogenetic analyses show that all four major genes originated through a single duplication event prior to the radiation of mammals.
The interpretation of this tree topology was that the GapC1 gene was produced by a single duplication of the gene encoding the cytosolic enzyme followed by changing sub-cellular localization from the cytosol to plastids [9], [10].
It supports a single duplication in the chelicerate-myriapod branch.
