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I happily took home a single dose to try.
Hence, the protocol was designed to determine the acute oral median lethal dose and evaluate the acute toxicity of fullerenes when administrated as a single dose to Sprague Dawley rats.
Trimetazidine was administered orally in doses of 5, 10 and 20 mg/kg (single dose) to observe its effect on the increasing current electroshock seizure (ICES) test in mice.
We have previously identified an effective regimen, 8 Gy given in three consecutive days (8GyX3), and an ineffective one, 20 Gy single dose, to induce T cell-mediated rejection of irradiated and synchronous non-irradiated TSA tumours with anti-CTLA4 (ref. 12).
Kobinger said he "would not expect" a single dose to work.
A first in human trial of an experimental treatment might involve a single dose to see whether humans can tolerate it.
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We chose single doses to approximate the previously reported doses from hepatoprotective animal experiment [ 23].
A hypofractionated regimen (2.5 Gy single-dose to 70 Gy, equivalent dose 75.1 Gy) led to acute rectal toxicity grade 2 or higher (RTOG criteria) in 7%, and to late toxicity grade 2 or higher in 6% (RTOG criteria) of the 400 patients treated from 2001 2005, with particular attention being paid to limit the rectal V70 [ 27].
Then cells were irradiated with single dose at 0 to 10 Gy with 6MV x rays.
We used a single dose, chosen to represent approximately equivalent multiples of the individual species' LD50 values.
A low efficacy of single dose albendazole to T. trichiura or a possible drug resistant is another concern [ 23].
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