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The decision for a single dose schedule at 14 months of age was based on epidemiological, programmatical and economical reasons [2].
A total of 51 patients were entered on the single dose schedule.
Similarly to what was observed with LMeC, the three-week dose schedule produced a better anti-tumour effect than the single dose schedule (p < 0.05).
Female BALB/c athymic mice were injected with human B02/GFP.2 breast cancer cells (a bone-homing subclone of MDA-MB-231) and zoledronic acid administered daily (intravenous 3 μg/kg preventive and 7 μg/kg therapeutic), weekly (20 μg/kg preventive and 50 μg/kg therapeutic) or as a single dose schedule (100 μg/kg preventive or therapeutic).
Similar(56)
The drug was again well tolerated with no significant weight loss observed in the single dose schedules.
Large-scale introduction of a MenCC vaccine has led to improved protection in adolescents, but in infants a single-dose schedule may not provide sufficient protection on the long-term and therefore a booster-dose early in adolescence should be considered.
The delegates made several recommendations, including (1) giving priority to developing a group A vs an A/C conjugate vaccine; (2) indicating a preference for a single-dose schedule; (3) favoring introduction through mass campaigns and into the routine Expanded Programme on Immunization (EPI) schedule; and (4) strengthening meningitis surveillance [ 11].
The AS03 Adjuvant System has previously been administered with H5N1 vaccines in a two-dose schedule to a large number of adults in clinical studies [ 7, 8] and more recently with A/California/7/2009 H1N1 vaccine as a single-dose schedule in mass vaccination campaigns in many countries.
Eighteen animals received BTZ 0.20 mg/kg as single dose ("acute" schedule) and 22 animals underwent an 8-week period of BTZ administration ("chronic" schedule, 0.20 mg/kg/day three times/week; see [ 28]).
HT29 tumours in vivo had similar DT-diaphorase activity [359 nmol of 2,6-dichlorophenol-indophenol (DCPIP) reduced per min per mg of protein] to the cell line (337) but failed to respond to a single dose or daily dose schedule.
Objective To determine whether the immunogenicity of a single dose infant priming schedule of serogroup C meningococcal (MenC) conjugate vaccine is non-inferior to a two dose priming schedule when followed by a booster dose at age 12 months.
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