Single dose regimens for IPT would be preferable to a course given over several days.
Selecting a single dosing regimen for all study participants is unlikely to accommodate the range of clinical and physiological characteristics encountered.
Consequently, the use of single dose regimen is particularly pertinent for settings with scarcity of health care workers.
13 There was no significant difference between doses equivalent to 20 mg (odds ratio 0.61 for laryngeal oedema, 0.32 for reintubation) and 40 mg (0.61, 0.47) methylprednisolone, with all confidence intervals including 1 in the single dose regimen.
We found possible dose dependent effects in multiple dose regimens but not in single dose regimens.
26 H5N1 vaccine trials before the pandemic showed the need for a two dose regimen in immunologically naive individuals, 19 and two dose regimens of several H1N1 vaccines are more immunogenic than single dose regimens.
For the simulation, as it had been proved that the efficacy of a single dosing regimen was better than doses administered every 24 h or 48 h of the same total amount of marbofloxacin [ 26], the EMA recommended dose regimen can be converted to 8 mg/kg BW with a single dose.
We selected the data closest to a single-dose regimen from those studies that used different dosing regimens in a single trial as our conservative strategy.
With the single-dose regimen we determined the parasitemia at 72 h postinfection, and for the triple- and quadruple-dose regimens we determined the parasitemia at 96 h postinfection using standard flow cytometry techniques or standard microscopy (25).
A novel microsphere formulation of azithromycin provides a single-dose regimen while maintaining tolerability.
