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They subsequently took a single dose of one of the randomly allocated preparations.
Enrolled adults received a single dose of one of 3 manufacturing lots of ACWY-TT (ACWY-TT group, lots A, B and C), or Mencevax™ ACWY (MenPS group), or ACWY-TT (lot A) co-administered with the seasonal influenza vaccine, (Fluarix™: GSK Biologicals, Coad group), respectively.
Enrolled healthy adults 18 55 y of age received a single dose of one of three manufacturing lots of ACWY-TT (ACWY-TT group, lots A, B and C), or Mencevax™ ACWY (MenPS group), or ACWY-TT Lot A co-administered with the seasonal influenza vaccine, (Fluarix™: GSK Biologicals, Coad group), respectively.
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All cohorts of subjects enrolled in this study received three ascending dose levels, as follows: Cohort 1 or 'sentinel groups': single dose of one eye drop solution of rhNGF 0.5 μg/ml (35 μl drop corresponding to 0.0175 μg of rhNGF), or 5 μg/ml (corresponding to 0.175 μg of rhNGF), or 20 μg/ml (corresponding to 0.7 μg of rhNGF).
Cohort 1 or 'sentinel groups': single dose of one eye drop solution of rhNGF 0.5 μg/ml (35 μl drop corresponding to 0.0175 μg of rhNGF), or 5 μg/ml (corresponding to 0.175 μg of rhNGF), or 20 μg/ml (corresponding to 0.7 μg of rhNGF).
A single dose of one gram azithromycin orally was either prescribed or handed out directly.
Thus, the beneficial effect of one single dose of db-cAMP on the proteasome effectively prevented protein aggregation upon short-term but not long-term treatment with PGJ2.
Within the sub-study (the Influenza cohort), subjects were randomized 1 1 1 1 1 to receive a single dose of ACWY-TT (one of three manufacturing lots); or Mencevax™ ACWY (MenPS group), or ACWY-TT co-administered with the seasonal influenza vaccine (Coad group).
Twenty-six patients received tamoxifen at a single dose of 20 mg; one woman received 40 mg for metastatic disease.
Subjects were distributed according to a computer-generated random number list, stratified by study center, to receive subcutaneously a single dose of 100 IU/Kg of one of the EPO preparations (A or B) in a parallel design.
The AUC after administration of one single dose of 1.5 mg LNG was greater than two doses of 0.75 mg with a 12 or 24 h interval.
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