Sentence examples for single dose levels from inspiring English sources

In the SRD part, six single dose levels were investigated which allowed an estimation of dose proportionality.

The study illustrated that both single dose levels used (3 mg and 30 mg) were effective in inducing a clinical response.

This study suggests that the combination of sorafenib and infliximab at full single dose levels should not be further evaluated in patients with advanced RCC.

Another limitation of the current study pertains to the single time point used for some of the data analyses, and the use of single dose levels for each inhibitor.

A similar safety profile (i.e. no serious bleeding or drug-related SAEs) for ALT-836 at a single dose levels up to 0.3 mg/kg was observed in 26 patients with CAD who were also receiving daily anti-platelet aspirin therapy [ 14].

If fewer than three of the six patients experienced a DLT, dose escalation was permitted, but if three or more of six patients experienced a DLT at a single dose level, that dose level was identified as the MTD.

If the toxicity occurred in two or more patients at a single dose level, then that dose was deemed intolerable and the next lower dose level was expanded to increase confidence in toxicity assessment at the MTD.

If however, two out of three or three out of six patients in a single dose level experienced DLT, then it was planned to stop recruiting at that level and to include additional patients at a lower dose level.

The acute toxicity of F8-IL10 was investigated in mice after intravenous administration of a single dose level of 20 mg/kg, corresponding to 300 times the human starting dose proposed for clinical trials [ 53], followed by a 14-day observation period.

The in vivo activity of poly HPMA)–GFLG AmB AleA conjugates was evaluated in the BALB/c mouse model at a single dose level of conjugate at 1 mg/kg amphotericin B equivalent × 3 and compared to single-drug conjugates that had shown in vitro activity.

Although these data were used in the optimization of the model, the small sample size and only a single dose level do not provide confidence that the data from Poiger and Schlatter (1986) represent the wide range of potential exposures and populations at risk.