Cisplatin induces a sensory neuropathy due to axonal damage that is dependent on the total-dose and single-dose intensity [ 12], and it is also time-dependent [ 13], making histological lesions more common than clinical toxicity.
The better performance of the polymersomes as a cell tracker agent is also shown by the enhanced fluorescence intensity over time after a single dose (figure 3c d).
In both studies, the increase in dose intensity was obtained by increasing the single dose per cycle while intervals between cycles were not reduced, that is, the dose density was not increased (Thor et al, 1998; Di Leo et al, 2002).
Locoregional chemotherapy to the authors' knowledge, never used before to treat EMPD was considered feasible because of the high dose intensity that can be achieved in single treatments, each of brief duration, which can be given under sedation.
Single-agent phase II studies of irinotecan in pancreatic carcinoma (dose intensity 100 mg m−2 week−1) have shown typical response rates of around 10%, again similar to other single agents (Wagener et al, 1995; Armand et al, 1996).
The concept of dose intensity is based on the hypothesis that a single or tandem exposure to very high doses of chemotherapy will eliminate any remaining tumour cells, and thereby result in a cure.
In 10 patients with positive [18]F-FDHT-PET, the tumor [18]F-FDHT uptake after one single dose of flutamide was significantly decreased with a mean drop in intensity around 60% [ 18].
While previous surveys [ 11, 14] in this field mainly have focused on the importance of single exercise regimes, the present study provides further investigations on the optimal dose (intensity) as well as the estimated hip joint loading during specific exercises.
(The calculated dose intensity for irinotecan is approximately 50% of that utilised in single-agent Phase I studies, 46 mg m−2 week−1).
This interference in the total fluorescence intensity measurement could be responsible for false negatives when screening at a single dose and applying a single "active" cutoff.
In this trial, a dose of 1125 mg m−2 gemcitabine on days 1 and 8 of each 21-day cycle was chosen since this dose leads to a dose intensity of 750 mg m−2 which1, whish isimilaras as the schedule in which single-agent gemcitabine 1000 mg m−2 is given weekly for 3 consecutive weeks in a 28-day schedule.
