There were three studies of between one and three months' duration: uricosuric amlodipine compared to tertatolol showed higher eGFR in the group treated with amlodipine [ 54]; creatinine clearance improved following a single dose infusion of rasburicase compared to placebo [ 55]; and there was a tendency towards higher eGFR in a comparison of benzbromarone to allopurinol [ 56].
In patients treated with single dose infusion of 135 and 175 mg/m given as 3- and 24-hour infusions, mean steady state volume of distribution has ranged from 198 to 688 L/m, indicating extensive extravascular distribution and/or tissue binding.
PK/PD studies in recent years have shown that extension of the single-dose infusion time can improve the efficacy of time-dependent antibiotics.
They divided subjects into 4 subgroups based on the route and method of ketamine administration: ketamine as single dose, continuous infusion, PCA, and epidural ketamine with opioids.
Antidepressant response to a single subanesthetic dose infusion of the glutamatergic modulator ketamine is transient in most depressed patients; however, a minority continue to experience an extended response.
Strategies to reduce this risk have included limitation of the total administered dose, administration in fractionated rather than single doses, as infusions, the use of protective agents and liposomal encapsulation of the compound (Weiss and Manthel, 1977).
Various risk factors have been reported concerning oxaliplatin-induced neurotoxicity, including treatment schedule, single dose per cycle, cumulative dose, infusion time, pre-existing peripheral neuropathy, and surgery [ 18].
Etomidate is known to cause adrenal suppression, both after a single dose and with prolonged infusion [ 2, 3].
The influences of treatment schedule, single dose per cycle, and infusion time were not analyzed as this safety analysis was focused on FOLFOX4 regimen in the six studies.
The main limitation of the study is that: The accuracy of serum osmolality estimation is only determined during single dose of hyperosmolar agent infusion.
Ferric carboxymaltose is a newer dextran-free iron formulation with a near neutral pH, physiological osmolarity and increased bioavailability which allows for single dose, short 15 minute infusion time and higher dosing (up to 1000 mg) [ 17].
