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Rapid waning of circulating antibodies was also observed in the UK after a single dose in the second year of life [7], [8].
At present, apart from the Netherlands, several other countries, such as Belgium, Cyprus, France, Germany, Luxembourg, and Monaco, have implemented a vaccination scheme with a single dose in the second year of life (Table 1).
Furthermore, a good surveillance programme is recommended for timely detection of vaccine breakthroughs and outbreaks among non-vaccinees, since long-term protection after a single dose in the second year of life cannot currently be guaranteed.
For this reason, when applying this vaccination scheme, i.e. a single dose in the second year of life without an addition booster dose, it is important to have a solid surveillance programme, in which the number of patients with serogroup C meningococcal disease is carefully being monitored in order to determine long-term vaccine protection.
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Also, emergency contraception of levonorgestrel (1.5 mg) in a single dose taken in the first 3 weeks of the menstrual cycle shortened that cycle.
Subcutaneous rhIGF-1 (120 μg/kg) per dose over two admissions: the first as a single dose and the second as twice daily doses over 5 days.
150µl was injected s.c. twice daily, and 300µl was injected in a single dose on the first and last day, per 30g mouse.
This study explored whether a single dose of the first full D1 agonist dihydrexidine DAR-01000) would cause changes in brain activity (perfusion) in dopamine-rich brain regions.
Whilst it should be noted that this study was not designed nor formally analyzed to assess dose proportionality, the data are consistent with previous data from the single dose first-in-human study and data observed in rats and dogs [unpublished data].
In a recent trial in Tanzania, single dose primaquine given on the third day of treatment with sulfadoxine-pyrimethamine (SP) plus AS reduced gametocyte carriage by more than 80% as compared to SP-AS alone [32].
Acute pain has been studied in single dose designs first proposed by Beecher and colleagues [ 1, 2] and formalized by Houde and Wallenstein [ 3].
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