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In the subanalysis of accumulated number of TNF-α inhibitor doses, the risk of serious infections was significantly increased in patients receiving a single dose (hazard ratio 1.64, 95% confidence interval 1.06 to 2.53) and decreased thereafter in those receiving two or three doses (1.18, 0.79 to 1.78) and four doses or more (1.06, 0.66 to 1.69, fig 2).
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The results obtained in this study indicate that both carbamates administered orally in a single dose are low hazard.
The Kaplan-Meier analysis (log-rank test p = 0.45) and Cox regression adjusted analysis indicated no significant difference in the time to clearance of parasitaemia between multiple and single dose rectal artesunate treatment (HR = 1.04 p = 0.76), the assumption of proportional hazards not being justified.
Seventy-six millioneedildren need single dose treatment.
A pouch amounts to a single dose.
But a single dose doesn't always work.
Take the administration of a single dose of chemotherapy.
This is a single dose approval for a single day and no more.
A single dose of radiotherapy could be more convenient for patients, Nice said.
The state could use four different three-drug methods or a single dose of pentobarbital.
With some sprays, a single dose works for as long as 12 hours.
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