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Moreover, a relatively larger dose was used in patients who received the repeated dose (100 140 U compared to 70 100 U in single dose group).
In contrast, homologous reactivity could be initially detected on single dose group (HI titer 30) which was robustly boosted in two-dose administrations (320 HI units).
Eleven pregnancies were reported, among them 7 were in the two-dose group and 4 in the single dose group.
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Lipid levels measured at 1 h before dosing in the single dose groups and at 1 h before dose 3 in the multiple dose groups served as baseline values.
For the single dose groups, blood samples were collected at 1 h before dosing and at 0.25, 0.5, 1, 2, 3, 4, 5, 6, 8, 12, 24, 48, 72 and 96 h after dosing.
Furthermore, a single dose-group urine pool composed of 200 μL of urine from each animal in the group was created and stored in a separate vial.
The single-dose group received an infusion of gentamicin and clindamycin, followed by an administration of intravenous placebo 8 and 16 hours later to maintain blinding.
The purpose of the current trial was to compare the relief of airway obstruction from treatment with a single dose of albuterol,7.5 mg (single-dose group), with that from three sequential doses of albuterol, 2.5 mg, spaced 20 min apart (multidose group).
13613_2016_168_MOESM1_ESM.xls Additional file 1. Dataset of single-dose group.
However, the single-dose group experienced significantly longer duration of effect (P = 0.032).
We enrolled in the study 39 consecutive patients (single-dose group).
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