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Except for survival curves, the canonical single dose fraction in conventional radiotherapy of 2 Gy was used for all experiments at a 2 Gy/min dose rate.
This radiation if applied as high single dose fraction, in most of cases of photons, is defined as radiosurgery (RS), also named by many authors as stereotactic radiosurgery (SRS).
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Single doses per fraction were 2.5 Gy calculated at the ICRU (1993) point.
Cells treated with a single dose of F4 fraction (31.2 μg/ml) induced G2 arrest (60%) as compared with a negative control (18%) ethanol (0.2%).
This targeting allows treatment of small-sized tumors in a limited number of single-high dose fractions.
The basic formula takes into account single dose, number of fractions, and the α/ β-quotient: BED= nd (1+ d/ α/ β), where n is the number of fractions; d the dose (Gy) per fraction; α/ β the LQ quotient.
Both cell lines were irradiated with a single dose, or daily fractions of 2 Gy, and 48 hours after the last dose the irradiated cells and controls were plated into serum-free conditions at clonal densities.
Our first observation was that DC were resistant to radiation, even following a single high-dose fraction of 30 Gy.
196– 198 Stereotactic radiosurgery uses three-dimensional planning techniques to precisely deliver narrowly collimated beams of ionizing radiation in a single high-dose fraction to small (<4 cm) intracranial targets.
If pelvic nodes were irradiated with adjuvant intent, a total dose of 50 Gy in 27 fractions with a single dose of 1.85 Gy per fraction was delivered.
SRT can be delivered as a single dose or in multiple fractions.
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