Sentence examples for single dose effects from inspiring English sources

Suggestions are made to routinely conduct a single dose toxicity study patterned after the neurotoxicity study design to distinguish single dose effects and NOAELs from those resulting from multiple doses.

Likewise, single dose effects of 15 mg prednisone were identifiable with some combinations of endpoints.

Ten datasets compared methylphenidate with placebo on brain function in medication-naïve patients in randomized controlled designs (4,16 18), including the new whole-brain re-analyses of four ROI datasets (22 24) (Table 4) and four datasets comparing single dose effects of methylphenidate/stimulants with off-medication in chronically medicated medication responders (19 21) (Table 4).

In order to evaluate the acute, single-dose effects of D-amphetamine administration on PDE10A, rats were treated with D-amphetamine (5 mg/kg, solution 2.5 mg/ml in saline, s.c. in awake animals) and were scanned with [18F]JNJ42259152 60 min after D-amphetamine injection (Experiment 1; n = 6).

Rectal biopsies for the microarray studies were obtained before treatment at enrollment (time point '0'), 30 60 min following application of the single gel dose (time point 'I'; to test acute single-dose effects), and again on the day following the last dose of the seven once-daily gel applications (time point 'VII'; to test multiple-dose effects).

HAPLIN can distinguish between single and double dose effects of haplotypes, but to reduce the number of parameters needed to be estimated in a multi-SNP scan, haplotype effects were assumed multiplicative in our analyses.

In an attempt to remove the confounding effect of sepsis on adrenal function, we studied a group of severely injured trauma patients to determine whether a single dose of etomidate effects adrenal function.

The technique of EP is a significant development for the field of gene therapy, given the ability to administer small amounts of plasmid in a single dose with significant effect [ 32, 33].

Metrifonate, an older drug no longer in use, had little effect when given as a single dose but an improved effect when given as multiple doses two weeks apart.

But in fact a single dose of nicotine has effects on the brain that can last as long as a month, and the nicotine obtained from just one or two puffs on a cigarette will occupy half of the brain's nicotinic receptors, the molecules specifically sought by nicotine in tobacco addiction.

The analysis of adequacy is performed for total dose effects, single event effects, displacement effects and transient radiation effects.