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The data overall confirm that formulations of botulinum toxins are not interchangeable, nor can they be converted by a single dose conversion factor.
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For ED evaluation, this dependence is reflected in CTDIvol and DLP parameters as well as in the dose conversion factor.
The dose conversion factor and the overall radiation risk represented by the effective dose is well within the range of what is known and well tolerated with other 18F-labeled tracers such as 19.0 μSv/MBq for [18F]FDG [18F]FDG
The Monte Carlo BEAMnrc code was applied in calculations of the dose conversion factor of water and polystyrene phantom: the dose conversion factor measurements were obtained by switching the TLDs at the same calibration depth of water and the solid phantom to measure the absorbed dose and verify the accuracy of the theoretical calculation results.
Moreover, the dose conversion factor (DCF) of radon decay products may vary by a factor of ∼40 within the particle size range from ∼0.5 nm to tens of micrometers.
An alternative explanation is that the initial peginesatide doses that resulted from tiered dose conversion tables were higher than those that resulted from a single dose conversion ratio.
Although median peginesatide doses also tended to increase in those cohorts in which tiered conversion tables were used, this effect was not as pronounced as it was in those cohorts in which single dose conversion ratios were used.
However, Cohort C (single dose conversion ratio) had a similar starting dose as did Cohorts G and H (tiered dose conversion tables), and the median dose for Cohort C increased substantially during the course of the study, whereas dose increases in Cohorts G and H were less pronounced.
For this purpose, MCNPX flux to dose conversion factors reused.
Dose conversion factors (S values) were taken from OLINDA/EXM 1.1 software and were used for calculation of organ and RM absorbed doses [12].
Convergence of the finite cloud approximation to the tabulated semi-infinite cloud values for dose conversion factors was validated.
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