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"Giving radiotherapy in a single dose at the time of surgery potentially offers a huge benefit, especially if it means fewer visits to hospital.
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Five published trials 11 12 13 14 15 mostly tested the effects of single doses at selected time points (which can arbitrarily advantage one drug because of the difference in times to maximum effect 16), were largely done in secondary care, and reached conflicting conclusions.
"I don't know if a single dose at one point in time is going to give you the long-term effects.
Patients on Pravachol, or pravastatin, were given half that dose, 40 milligrams a day, because that was the maximum allowable dose at the time.
In conclusion, a single dose of GnRH at the time of estrus or 7 days post-mating could be used as an effective protocol to decrease pregnancy loss from Day 40 after mating to parturition in low-prolific Rahmani ewes.
A single dose of peramivir at the time of infection (D0 single) provided a significant improvement in weight loss, leading to protection in 50% of animals (P < 0.0005).
A 1.5-log10 1.5-log10 in vireductionwas also found in animals treated with a single dose of peramiviralt the time of infection (P < 0.05).
A single dose was administered at time zero and observations were taken at asymmetric timepoints.
In a second experimental setting we embedded non-irradiated aortic rings in collagen gels and irradiated them two days later (8 Gy, single dose), a time at which sprouting had already started.
The single dose was applied at the same time as the last dose of fractionated radiation.
To better control the time of RA exposure, we systematically administered a single dose of RA at times after mating ranging from 200 to 224 hours post coitum (hpc).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com