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It is also a single-centred study with a relatively small number of participants.
In Arabi's mixed medical and surgical ICU single-centred study, 623 patients were randomly allocated to either intensive insulin therapy (aiming to keep glucose levels between 4.0 and 6.1 mmol/L) or conventional insulin therapy (between 10.0 and 11.1 mmol/L).
A single-centred retrospective study was conducted in children undergoing cardiac surgery with Cardiopulmonary bypass (CBP) between September 2010 and May 2011.
Herzig and colleagues undertook a large single-centred cohort study of the effect of acid-suppressing medications on the incidence of hospital-acquired pneumonias [ 7].
County centred study in Norway involving primary and specialist care.
Single-centred observational studies or clinical trials were not considered for this review.
Methods Single-centred retrospective observational study analysing patient charts on the medical and surgical ICU of the University Hospital Basel from 2011 until 2015.
8 10 Published reports of ERCP-related AEs have all been single-centred or multicentred studies from tertiary care centres and affected by referral bias, leading to high estimates of risk that may not apply to the general population.
The generalisability of our results may be limited by the single-centred nature of the study.
We would suggest a further multi-centred study may be required to demonstrate such a difference.
An appropriately powered multi-centred study examining the treatment and cost effectiveness is now planned.
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