This was a retrospective single centre study conducted at the Hyogo College of Medicine in Japan.
This was an open-label, phase II, two arm, randomised, single centre study conducted at Samsung Medical Center, Seoul, Korea.
In a prospective randomized single centre study conducted in 765 cardiosurgical ICU patients, van den Berghe and coworkers [ 7] showed that TGC decreased mortality and morbidity substantially.
This figure is considerably lower than the 3.7% observed in the USA [ 6] and 8.6% in a single centre study conducted in a French ICU [ 18].
This was a single centre prospective study conducted in the intensive care unit of a tertiary care teaching hospital.
This model is ideally suited to single centre research studies conducted by investigators based in that centre.
The present study was a prospective, single centre, observational study conducted during a 21 months period, between October 2009 and June 2011, in the General Surgery Department of São Francisco Xavier Hospital.
This retrospective, single centre study was conducted to investigate the efficacy of fibrinogen concentrate (FBNc) in decreasing blood requirements and reaching optimal fibrinogen level, in non-trauma, massively transfused, bleeding patients with coagulopathy.
Two of these studies were multicentre European trials conducted by the Early Clinical Trials Group (ECTG) and the Clinical Screening Group (CSG) of the EORTC, and two were single-centre trials conducted in the USA by the MD Anderson Cancer Center MDACCC) and the Memorial Sloan Kettering Cancer Center MSKCCC) (Aapro et al, 1994; Francis et al, 1994; Piccart et al, 1995; Kavanagh et al, 1996).
An open, controlled, prospective, randomized, single-centre trial conducted between February 2010 and June 2012.
