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One of them was being a single centered study.
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Patients and methods: A prospective single center study.
Patients and methods: This is a prospective single center study.
Third, this is a single center study that limits its application to other settings and centers.
This study was conducted as a prospective single center study including 110 consecutively admitted ICU patients.
Patients and methods: Prospective single center study in a 12 bed university ICU.
This was a single center study, which might not represent the whole population.
Being a single center study, it may have been subject to local bias.
Materials and methods A prospective observational single center study was performed in the ICU.
A cross-sectional, single center study performed in a mixed ICU.
Methods: Prospective single center study was developed according with the previous protocol.
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