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Despite this, a single causative gene is yet to be identified, largely due to substantial genetic heterogeneity.
Infertility is a complex disease, and hence an approach to identify a single causative gene is incomprehensive.
Although three chromosomes provided suggestive linkage signals, their coexistence in one family hardly supports the idea of a single causative gene.
The genetic susceptibility of an individual to such a disease appears not to be the result of a single causative gene but rather arises from multiple interacting genes.
From a genetics perspective, our model is a more complex scoring function for the identification of a single, causative gene instead of the conventional multi-gene QTL interval.
However, factors such as multiple linked QTL in the region, multiple alleles for a single causative gene, non-additivity of founder genotypes, or variation in the frequency of founder genotypes in the two populations could make the effects at our QTL difficult to estimate or interpret.
Similar(54)
There is no single causative agent of bacterial vaginosis.
Median severity of AGE cases with a NoV as single causative agent was 14, and with a RV as a single causative agent, median was 16.
We considered NO2 a proxy estimator of exposure to air pollution, not the single causative agent.
We report a novel autosomal recessive phenotype in a single family and identify the causative gene.
Similarly, if genes respond to the same transcriptional regulators with the causative, adaptively plastic genes, the correlated response will make it difficult to single out the causative genes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com