Exact(12)
Notice that a chromosome may only have one single altered SNP according to the CNAG's output; therefore, we also exclude those chromosomes in the comparison in order to reduce the false positives.
Thus, to expect a strictly linear sequence of events [single microRNA change → single altered protein → single phenotypic alteration] would be to disregard the exquisite complexity of miRNA regulatory networks.
Some pathways involved a single altered gene, in others 2 or 3 predominant genes were altered, and other pathways showed alteration of many genes.
Yet the type of sequence variation portrayed here, caused by a single altered nucleotide, accounts for most of the genetic differences among humans.
The discovery of this single altered gene, Dr. Austad said, "gives us something quite specific that we can look at quite easily".
They found a point mutation in the gene (a single altered base pair) in one of 91 randomly selected short individuals, and no such mutations in 300 people of average height--suggesting that about 1% of all short people may carry a SHOX mutation.
Similar(48)
Among various single mutants altered in these target residues, R264H evidenced noticeably increased reductase activity with NADH.
This single event altered my doe-eyed innocence, and since then I became more attuned to people's behavior towards me and wondered, what were they really thinking?
From the reign of Edward IV the crown bore a single arch, altered to a double arch by Henry VII.
Not a single gene altered in both in vitro systems was also altered in vivo.
Thus, a single allele altered plasma TG levels by approximately 5%.
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