Sentence examples for single agent toxicity from inspiring English sources
Use of lower drug concentrations (10 μM) limits the single agent toxicity, which can also allow for identification of synergistic interactions with TRAIL.
Although single agent toxicity of sunitinib is well known we chose toxicity as primary end point since excessive toxicity of the combination may impair completion of standard radiation therapy and surgery.
We therefore aimed to investigate whether concentrations of bortezomib with only low single-agent toxicity synergise with TRAIL in HPV+ HNSCC cells.
There is also a rationale for combining targeted agents that hit complementary pathways, but to date there are few confirmed examples of combined targeted agents being better than single agents, and toxicity is often increased.
Given their demonstrated activity as single agents and toxicity profiles, including myelosuppression and gastrointestinal adverse effects, most studies focus on maintenance treatment after chemotherapy rather than combinations with antineoplastic drugs.
Here, we report durable disease control in an elderly chemo-naive patient with MPM, obtained with pemetrexed single agent, without significant toxicity.
Drugs were first pre-screened individually (single agent treatment) for toxicity at a concentration of 20 μM using TRAIL-resistant PC3-TR prostate cancer cells; candidates that resulted in greater than 70% reduction in cancer cell viability were screened for TRAIL sensitization activity at a lower concentration of 10 μM.
Carboplatin/paclitaxel every 3 weeks is the standard for patients with ovarian cancer, but elderly patients frequently receive modified schedules or single agent chemotherapy to avoid toxicity.
Owing to some single agent efficacy, a nonoverlapping toxicity profile and a difference in mechanism of action, raltitrexed is an interesting agent to combine with gemcitabine.
The rationale for combining topotecan and vinorelbine for recurrent lung cancer is primarily based on single agent activity and different toxicity profiles.
Similarly, switching from a 5-fluorouracil based therapy (e.g. FOLFOX) to single agent capecitabine due to toxicity in a stop-and-go approach is an acceptable regimen, and it cannot be distinguished from salvage capecitabine after failure on 5-fluorouracil in claims analyses.
