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In rats, a single administration of acrylonitrile (vinyl cyanide) produces a rapidly occurring bilateral adrenal apoplexy.
Rats received a single administration of control or ethanol liquid diet and had free access to water and standard rodent chow throughout the duration of all experiments.
In the rats fed normal diets, a single administration of EEA at 600 mg/kg significantly increased stool frequency and weight.
Recently, we established the fact that pre-administration of the aqueous and ethanolic extracts of Dennettia tripetala can protect the liver and kidney of rats from damage arising from a single administration of carbon tetrachloride [16, 17].
Nephrosis was induced in male Sprague Dawley rats (160-200 g, Charles River, France) by a single administration of PAN (150 mg/kg body wt, jugular vein).
Single administration of ETN before MCAO significantly suppressed exacerbation of cerebral damage in nondiabetic rats, as assessed by infarct volume.
In 16-week male old Sprague Dawley (SD) rats (300 to 350 g), insulin-dependent diabetes was induced by a single administration of streptozotocin (60 mg kg−1; i.p).
Additionally, single administration of c-SOM into the VLO failed to alter tail reflex latencies and formalin-induced nociceptive behaviors in female rats.
We previously reported that single administration of ibogaine, an indol alkaloid with antiaddictive properties, dose dependently reduced alcohol intake in three strains of alcohol-preferring rats.
Toxicity of the aqueous extract was evaluated in both male and female wistar rats after a single administration (Acute model) and during 21 days (subacute model).
For i.v. self-administration, doses were prepared daily on a per rat weight basis from stock solutions.
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