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Since the initial demonstration (Opt. Lett. 26 (2001 12455) the spectral range has been broadened by two orders of magnitude and the channel number has been improved by nearly one order of magnitude.
Since the initial demonstration that these molecular subtypes correlated with differences in survival [ 2], other groups have similarly confirmed the clinical relevance of the biologic subtypes [ 3, 4].
Since the initial demonstration that ADPG serves as the precursor molecule for bacterial glycogen biosynthesis, it has been considered that ADPG pyrophosphorylase (GlgC) is the sole enzyme catalyzing the production of ADPG in these organisms.
Since the initial demonstration of this specificity, numerous PARP inhibitors have entered clinical trials (including AZD-2281 (OlAstrab, Astra Zeneca), ABT-888 (Abbott), BSI-201 (BiPar sciences), MK-4827 (Merck) and AG-14699 (Pfizer)).
Since the initial demonstration of this system in the yeast Saccharomyces cervisiae, optical mapping has been used to validate and assist the reconstruction of multiple genomes ranging from bacteria [ 3] to the human genome [ 4].
DOI: http://dx.doi.org/10.7554/eLife.00704.002 Since the initial demonstration that mitochondria take up substantial amounts of cytoplasmic Ca2+ (Deluca and Engstrom, 1961), detailed studies have revealed that this uptake can sculpt the cytoplasmic Ca2+ transient (Wheeler et al., 2012), enhance ATP synthesis (Balaban, 2009), and trigger cell death (Zoratti and Szabo, 1995).
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Since the initial demonstrations that the CRISPR/Cas9 system could be used for genome editing in C. elegans, several strategies have been used effectively, and significant improvements have been made to facilitate the generation and identification of edited animals.
Last week, there was the initial demonstration, where students were voicing their displeasure.
Mr. Dans arrived at the initial demonstration late and was stunned at the turnout.
Some participants needed further help after the initial demonstration, highlighting the importance of technical support and digital education.
We first determined the cost of the IPC as implemented in the initial demonstration.
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