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The creation of lentiviral vectors with highly engineered EboZ envelopes improved the performance of the system and should also increase its safety since only minimal regions of the EboZ envelope, which lack the toxic domain, are used.
This research paper emphasized that HME is a robust process throughout the experimental design space for obtaining amorphous glassy solutions and for tabletting of such formulations since only minimal impact of the process parameters was detected on the extrudate and tablet properties.
The potential of this approach for clinical diagnostics is huge, since only minimal biological preparation is necessary.
The echinocandins probably do not exert their antibiofilm effects primarily on the fungal cell wall since only minimal cellular changes have been observed on biofilm-associated Candida cells.
Moreover, it is emphasized that such pH-responsive diblock copolymer nano-objects differ from conventional pH-responsive weak polyelectrolytes since only minimal amounts of base (or acid) are required to induce the change in copolymer morphology.
In contrast, expression of the therapeutic proteins in crop seeds has a great advantage for oral administration since only minimal treatment is necessary to use seeds as the livestock fodder.
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Since the peptide substrates used in these assays are poor models for the complex and dynamic structure of the chromatin substrate in cells and since the only minimal number of PRC2 proteins (EZH2 EED SUZ12) required for enzymatically active EZH2 were employed in the PRC2 assay, care should be taken in the over interpretation of this in vitro inhibitory data.
On the other hand, since there was only minimal reduction of FTO in the brain tissues of the gene-trap mice comparing to other tissues (Figure S1C), we reasoned that Fto might function in the brain, To explore this possibility, we deleted Fto in the nervous system by crossing Ftoflox allele with the Nestin-Cre transgenic mice [38] (Figure 7A).
The estimation of CNs from the HC ratios is intrinsically problematic, since ratios provide only minimal CNs and any multiple of that can be ruled out only by additional considerations (NA18858).
Some animals were used in more than one procedure since the experiments had only minimal effect on the animals.
The stadium replaces a field that had been in use since the 1930s, with only minimal renovations over the years.
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