Sentence examples for since its activation from inspiring English sources
TREM2 seems to be crucial for brain homeostasis, since its activation stimulates the phagocytic activity in microglia without causing inflammation [ 117].
It behaves like a pattern recognition receptor (PRR) since its activation leads to the release of pro-inflammatory cytokines, namely of tumour necrosis factor-alpha (TNFα) and of interleukin (IL -8.
The school now turns out literates at a rate of 200 a week, and since its activation on Jul. 12, 1943, has graduated something over 13,000 men.
The phosphorylation of BADS is unlikely to involve Akt since its activation is extremely low in βIRKO cells (see below).
In particular, the P2X7 receptor has attracted considerable interest since its activation triggers maturation and release of proinflammatory IL-1 β in monocytes and macrophages [ 46].
Sog is not expressed in dl-dpp double mutants since its activation is strictly dependent on Dorsal like in all other insects studied so far except in Oncopeltus.
C-terminal phosphorylation of IRF3 is a critical step for its activation since it allows its homodimerization and nuclear translocation.
Erk1/2 signalling is particularly relevant for AD since its aberrant activation is an important driver of neurodegeneration [ 109, 110].
The participation of NF-κB in memory consolidation and reconsolidation processes constitutes an evolutionary conserved feature, since it was shown that its activation is a necessary mechanism in crabs and mice [18], [21], [22], [33], [34].
Phosphorylation of this Vav1 site is a good reflection of its activation status, since it has been shown before that this posttranslational modification induces a conformational change in the Vav1 molecule that stimulates its GDP/GTP exchange activity towards Rho/Rac proteins [27] [29].
Since E2F1 acetylation reflects its activation augmenting DNA binding and stabilizing the protein (Martínez-Balbás et al., 2000) thereby enhancing its transcriptional activity, we evaluated the amount of acetylated E2F1 in WT, A1-KO, A2-KO and A1/A2-KO MEFs by western blot analysis using antibodies specific for the acetylated form of E2F1.
