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This study is framed within a social constructivist approach, since alignment between the affordances of social media and the premises of social constructivist learning theories (Dron & Anderson, 2014) are well established.
Since alignment on S4KS arrivals is usually unstable, differential times between S4KS and S5KS (called d t 5−4) are calculated by subtracting d t 4−3 from d t 5−3 with error propagation.
This is a key advantage of targeted assembly, since alignment of NGS sequence to a complete reference would not be expected to return sequence reads that contained a significant number of non-reference bases.
This is necessary since alignment regions with not exactly overlapping gap segments in chimp and rhesus cannot be explained by only one insertion event.
Data from the MOST study suggest an association between alignment of the knee and progression of BML mediated through increased mechanical load in a compartment-specific manner, since alignment is believed to influence load distribution [ 21].
The XPMSS pump-probe delay scans exhibit a characteristic dispersive shape, since alignment of the probe with the rising or falling slopes of the pump pulse shifts the spectrum in opposite directions.
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Since alignments can be ranked, correct assignments will be saved as unique alignments in the first filtering step (Figure S1).
The enrichment of SU HW) at +40 kb can not be explained by a subgroup of specifically sized LADs, since alignments of subgroups of differently sized LADs all result in an enrichment at ∼40 kb (data not shown).
The domain assignment made at this step determines which database will be used for subsequent analyses, an important consideration since alignments were built separately for the eukaryotic sequence database and the bacterial and archaeal sequence database.
We used a total of 13 vertebrate genomes with over 6X coverage and high quality since alignments containing low-coverage genomes cause misalignment.
We emphasize that our analysis provides an estimate of the lower bound on the difference between optimal and heuristic solution, since alignments generated by MaxPairs are not always optimal (in the strict sense).
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