Sentence examples for simultaneously to inhibit from inspiring English sources
However, after 16 h, JNK inhibition diminished ROS production simultaneously to inhibit NOX4 expression suggesting that, at this time, NOX4 activity sustains ROS production in a JNK-dependent manner.
The first super-complex is similar to that proposed for SXL which binds poly(U) RNA and U1 snRNP simultaneously to inhibit the splicing of exon 3 [20].
106 To enhance the acceptability and adherence of vaginal/rectal microbicides, MPTs are being developed that aim simultaneously to inhibit HIV-1 infections and other STIs.
On the other hand, since a single miRNA can have multiple targets, it is very likely that miR-205 may also regulate other genes simultaneously to inhibit breast tumor growth.
Recently, there is evidence showing that using rapamycin and an AKT1 inhibitor simultaneously to inhibit the PIK3CA-AKT1-MTOR pathway facilitated the autophagy and produced synergistic effects on autophagy-mediated apoptosis.
An alternative strategy could be the use of agents designed to inhibit simultaneously multiple cellular targets relevant to tumour growth/survival.
The design, synthesis, and pharmacological evaluation of donepezil indolyl based amines 7 10, amides 12 16, and carboxylic acid derivatives 5 and 11, as multipotent ASS234 analogs, able to inhibit simultaneously cholinesterase (ChE) and monoamine oxidase (MAO) enzymes for the potential treatment of Alzheimer's disease (AD), is reported.
Indeed one intriguing possibility is that 2- O-Bn-InsP5 is more active than InsP5 because of its unique capability to inhibit simultaneously and very specifically PDK1 and mTOR.
The ability of benfotiamine, a lipid soluble thiamine, to inhibit simultaneously the hexosamine pathway along with AGE formation and PKC pathways might be clinically useful in preventing the development and progression of diabetic pathogenesis arising due to hyperglycemia-induced vascular damage.
This implies that fluorinated pyrimidine analogs could be used to inhibit both enzymes simultaneously.
18,21,25,26 Thus, targeting two aspects of metabolism, using DCA to promote mitochondrial activity and then an anti-mitochondrial agent to simultaneously inhibit mitochondrial function, is a rational approach to cancer therapy.
