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The combinational strategy has also shown efficacy when combining therapeutic antibodies with cytotoxic agents, as well as simultaneously administrating two or more therapeutic antibodies.
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Cassette dosing is also known as N-in-One dosing: several compounds are simultaneously administrated to a single animal and then the samples are rapidly detected by LC MS/MS.
Anticoagulants and anti-platelet agents are simultaneously administrated in clinical practice (i.e. percutaneous coronary intervention), which cause significant risk of systemic bleeding.
After the pre-treatment of the cells with iberiotoxin (100 nM), the mixture of 100 nM martentoxin and 100 nM iberiotoxin was simultaneously administrated, the remaining outward currents by 100 nM iberiotoxin alone were not significantly different (If: 0.14±0.02 compared to 0.17±0.02, p>0.05,n = 4) (Fig. 2).
C57BL/6 mice received 4 doses of DNA-Sm14 (100 μg/dose) and DNA-Hsp65 (100 μg/dose), simultaneously administrated, or DNA-Sm14 alone, once a week, during four weeks.
Two-way ANOVA statistical analysis of the data shows a significant difference in the mean values among the different concentrations of oxaliplatin (P<0.001) when simultaneously administrated with AZD1152-HQPA in HCT116 cells.
The results showed that the protein binding ability is not influenced when they are administrated simultaneously.
Specific inhibitors of different biochemical steps were administrated simultaneously with either CdSO4 or topoisomerase-1 inhibitor camptothecin (CPT).
c) In low-income countries and some middle-income countries RV vaccines have been administrated simultaneously with OPV (Table 4 ).
If CPT-11 and S-1 are administrated simultaneously, S-1, a prodrug of 5FU, might inhibit the anti-tumour activity of CPT-11.
When Gris was administrated simultaneously with CHENO or URSO, PROTO IX levels in feces were similar to their respective controls (Table 1).
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