Second, the discordance between simultaneous progression suggests that both structure and function contain complementary information.
The model is framed by the simultaneous progression of disease through major categories of complications and their associated Markov states (online appendix Fig. 1) (Microsoft Excel 2000, Microsoft, Seattle, WA; and @Risk 4.0 for Windows, Palisades, Newfield, NY).
The deposition of amyloid pathology in the brain and simultaneous progression of neurodegeneration are hypothesized to be the first change in the largely sequential pathological cascade of Alzheimer's disease (Ingelsson et al., 2004; Jack et al., 2013).
However, responders in the BPC cohort peaked markedly higher than nonresponders, which could be a result of near-simultaneous tumor progression.
Results at the different locations for different metabolites initially seem complicated, but are more easily interpreted if they are viewed as snapshots of two simultaneous temporal progressions – sequential involvement of the anatomical locations, and sequential abnormalities of the metabolites.
In the present study, radiologically, gradual enlarging of TWCLs simultaneous with gradual progression of fibrosing interstitial pneumonia was observed despite smoking cessation in 5 CPFE patients with TWCLs.
Transition from state 2 to state 3 is not directly observed in the data and is estimated based on the transitions from state 1 to 2 and from state 1 to 3. In general, for simultaneous estimation of progression parameters, a likelihood function is constructed, which includes all the information about the unknown parameters.
Although late toxicity cannot be excluded as a cause, the simultaneous evidence of disease progression in all 3 patients, at 6.8, 7.6, and 8.5 months, respectively, suggested that these symptoms were probably associated with progressive disease.
The precise mapping of these pathways may be very important before trying to interfere in tumor progression, since simultaneous genes should be targeted by therapy to reach a considerable benefit.
The exhibition of Mohamedi's delicate, exacting, wordless drawings, elegantly installed in the low-ceilinged Breuer building and accompanied by impressive photographs and notebooks, does precisely what Wagstaff was brought in to do: it rewires the history of modernism into something more complex and more simultaneous than the flow-chart progression many western museums still often indulge.
Efficient DNA damage repair and simultaneous regulation of cell cycle progression is critical for genomic stability.
