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In this paper, we introduce "Realtime Cerebellum (RC)", a new implementation of our large-scale spiking network model of the cerebellum, which was originally built to study cerebellar mechanisms for simultaneous gain and timing control and acted as a general-purpose supervised learning machine of spatiotemporal information known as reservoir computing, on a graphics processing unit (GPU).
Simultaneous gain of the chromosome X and chromosome Y was detected in 0.02% of cells in one brain sample only.
Correspondingly, few clusters show simultaneous gain and loss of different marks.
Simultaneous gain of 1q and loss of chromosome 6, and 13q aberrations frequently detected in type B3 thymomas.
The simultaneous gain of NUPR1 and ERBB2 can be a significant predictor of poor prognosis in EBC.
The results of this study are consistent with the previous reports that high Pi induces calcification and phenotypic conversion of VSMCs that involve the loss of VSMC differentiation markers, such as SM α-actin and SM22α, and the simultaneous gain of osteogenic phenotype, for example, expression of Runx2 [ 12].
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You also need changes in the energy world that open up space for progress that can deliver simultaneous gains on multiple fronts.
For example, C. reinhardtii (type C) hop and chl- fus conserved a plethora of introns (simultaneous intron gain?), while both genes in O. lucimarinus (type A) preserved only one (simultaneous intron loss?).
However, based on the principle of parsimony, if orthologous genes are present in multiple species but absent in just one, a single gene loss event is more plausible than multiple simultaneous gene gain events [ 17, 18].
In fact, theoretical modeling indicates that these processes can become even more extreme in hermaphroditic species (N.K. Michiels and J.M. Koene, unpublished data), mainly because within one mating simultaneous hermaphrodites gain paternity (male fitness) which can outweigh the loss in female fitness.
Our previous array-based analysis showed that copy number gains and losses of hundreds of genes are associated with a simultaneous increase or decrease in gene expression [ 17].
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